Carolina has only played Houston four times in franchise history, the fewest of any opponent. However, there are plenty of connections and storylines that make this week's contest in Houston very compelling.
Take a look at what the Texans players and staff are saying ahead of Sunday's matchup:
We heard Eric's side of the matchup, now hear from Texans safety Justin Reid, Eric's younger brother. READ MORE>>>
Justin even shared the Panthers sibling rivalry graphic on his Twitter account. Things should be fun on Sunday.
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Texans defensive coordinator Romeo Crennel, a long-time adversary of Panthers offensive coordinator Norv Turner, breaks down the Panthers offense. WATCH >>>
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The Texans' John Harris breaks down three keys to Houston's success in playing the Panthers in his weekly video series. WATCH >>>
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Both the Texans and Panthers started with the same head coach, Dom Capers. READ MORE >>>
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Texans fullback Cullen Gillaspia reflects on his relationship with Panthers quarterback Kyle Allen as the two were teammates in college. WATCH >>>
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Watt picked up his first two sacks of the season in Week 3 against the Chargers. READ MORE >>>
Carolina is 3-2 all-time against the Texans.
Carolina Panthers defensive tackle Terrell McClain (97) against the Houston Texans in the first quarter of an NFL football game Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers tight end Richie Brockel (47) rushes for a seven-yard touchdown as Houston Texans strong safety Glover Quin (29) defends in the second quarter of an NFL football game on Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers quarterback Cam Newton (1) flips into the endzone for a touchdown during an NFL football game against the Houston Texans at Bank of America Stadium on Sunday, September 20, 2015 in Charlotte. The Panthers defeated the Texans 24-17. (Perry Knotts via AP)
Houston Texans tight end Joel Dreessen (85) cannot quite get to the ball as Carolina Panthers strong safety Jordan Pugh (29) defends during the third quarter of an NFL football game on Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers quarterback Cam Newton (1) against the Houston Texans in the second quarter of an NFL football game Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers tight end Richie Brockel (47) celebrates a touchdown against the Houston Texans as Texans fans look on in the second quarter of an NFL football game on Sunday, Dec. 18, 2011, in Houston. (AP Photo/Dave Einsel)
Carolina Panthers running back Jonathan Stewart (28) is tackled by Houston Texans strong safety Glover Quin (29) in the second quarter of an NFL football game on Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers wide receiver Steve Smith (89) makes a touchdown catch with Houston Texans defender Jamie Sharper (55) in pursuit, during the first quarter, Sunday, Nov. 2, 2003, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers wide receiver Steve Smith (89) catches a pass against the Houston Texans in the second quarter of an NFL football game Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Houston Texans quarterback Ryan Mallett (15) scrambles with the ball under pressure from Carolina Panthers defensive end Charles Johnson (95) during an NFL football game at Bank of America Stadium on Sunday, September 20, 2015 in Charlotte. The Panthers defeated the Texans 24-17. (Perry Knotts via AP)
Carolina Panthers' Steve Smith (89) slips past Houston Texans' Von Hutchins, bottom, for a touchdown in the first quarter of a NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. (AP Photo/Chuck Burton)
Houston Texans wide receiver Bryant Johnson, center, and Carolina Panthers Captain Munnerlyn (41) and Jordan Senn in the first quarter of an NFL football game Sunday, Dec. 18, 2011, in Houston. (AP Photo/David J. Phillip)
Carolina Panthers' DeAngelo Williams (34) runs past Houston Texans' Jamar Fletcher (21)in an NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. (AP Photo/Chuck Burton)
Houston Texans' Ron Dayne (36) runs past Carolina Panthers' Deke Cooper (35) in an NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. (AP Photo/Rick Havner)
Carolina Panthers quarterback Cam Newton (1) looks to throw the ball downfield during an NFL football game against the Houston Texans at Bank of America Stadium on Sunday, September 20, 2015 in Charlotte. The Panthers defeated the Texans 24-17. (Perry Knotts via AP)
Houston Texans defensive end J.J. Watt (99) works against Carolina Panthers tight end Greg Olsen (88) during an NFL football game at Bank of America Stadium on Sunday, September 20, 2015 in Charlotte. The Panthers defeated the Texans 24-17. (Perry Knotts via AP)
Carolina Panthers' Steve Smith (89) breaks the tackle of several Houston Texans players for a 74-yard touchdown in the fourth quarter of the Panthers' 34-21 loss to the Texans in an NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. (AP Photo/Chuck Burton)
Houston Texans' Andre Johnson (80) runs past Carolina Panthers' Dan Morgan (55) for a 31 yard touchdown in the first quarter of a NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. (AP Photo/Rick Havner)
Houston Texans' Owen Daniels, right, loses the ball as he is hit by Carolina Panthers' Deke Cooper (35) and Chris Harris, top, in the first quarter of a NFL football game in Charlotte, N.C., Sunday, Sept. 16, 2007. The Panthers recovered the ball. (AP Photo/Chuck Burton)
Carolina Panthers tight end Jermaine Wiggins (84) fails to catch a pass in the end zone as Houston Texans Jamie Sharper (55) defends in the third quarter Sunday, Nov. 2, 2003, in Houston. The Texans won 14-10. (AP Photo/David J. Phillip)
