CHARLOTTE — The Panthers did everything they could, defensively.
Offensively, they again struggled.
The Panthers lost 26-16 to the Cardinals Sunday at Bank of America Stadium, a rough performance for an offense that hadn't looked particularly cohesive in any of the first three games.
It was a tough day from start to finish for quarterback Baker Mayfield, who threw two interceptions and managed just 197 passing yards.
The Panthers continued to sputter on third downs, converting just 2-of-10, and creating a down-the-line problem for a defense that's exhausted.
Mayfield's first four games have been rough as a whole, with a few moments of clarity but no consistent themes. He got hot for a few passes in a row to DJ Moore (more involved, which helped) and found Christian McCaffrey on a few passes late, including a touchdown. But once again, Mayfield was getting balls batted down at the line of scrimmage.
And while they were able to rely on McCaffrey over the last few weeks (he had two straight 100-yard rushing games), he had just eight carries on the day (for 27 yards).
It's a chicken-egg problem, because until they can extend drives, they can't establish the run, and the passing game isn't able to do that right now.
— Once again, linebacker Frankie Luvu was all over the place, and he had the biggest score of the day.
His 33-yard interception return for a touchdown in the first quarter continued a run of stellar play.
Last week, he created the first turnover of the season by ripping out a fumble that Marquis Haynes Sr. returned for a touchdown, sparking a three-turnover outburst that led to a win over the Saints.
Sunday, there was no follow-up act.
Luvu's playing incredibly well, but his frustration began to show late in the game, when he was flagged for unnecessary roughness for slamming running back James Conner to the ground.
— The Panthers played most of the game without safety Jeremy Chinn, who left early with a hamstring injury and did not return.
They played mix-and-match defenses most of the day afterward, with Sean Chandler subbing for Chinn at points, but using other personnel groupings to make up for the dynamic safety.
Without knowing the specific coverage, it's hard to place blame with any degree of accuracy at the moment, but Chandler was trailing tight end Zach Ertz on the game-tying touchdown in the third quarter.
The Panthers also were without Laviska Shenault Jr. in the second half after he left with a hamstring injury.
— Eddy Piñeiro nailed a 54-yard field goal just before the half, keeping the new kicker perfect so far on the season.
He entered the game a clean 7-of-7 on field goals, after replacing the injured Zane Gonzalez just before the start of the regular season.
View best in-game photos from Carolina's game against Arizona.

Arizona Cardinals wide receiver Marquise Brown is tackled by Carolina Panthers linebacker Frankie Luvu during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)

S - 42 - Sam Franklin
P - 10 - Johnny Hekker

S - 27 - Marquis Blair
TE - 84 - Stephen Sullivan

CB - 26 - Donte Jackson
DE - 53 - Brian Burns

CB - 8 - Jaycee Horn

LB - 49 - Frankie Luvu
LB - 7 - Shaq Thompson

T - 72 - Taylor Moton
T - 75 - Cameron Irving

T - 75 - Cameron Irving
LB - 57 - Damien Wilson
DE - 98 - Marquis Hayens

QB - 6 - Baker Mayfield

CB - 26 - Donte Jackson

TE - 80 - Ian Thomas

Carolina Panthers tight end Ian Thomas is tackled by Arizona Cardinals linebacker Isaiah Simmons during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)

Arizona Cardinals linebacker Tanner Vallejo forces a fumble by Carolina Panthers wide receiver Shi Smith during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. The Panthers recovered. (AP Photo/Jacob Kupferman)

Carolina Panthers wide receiver Shi Smith runs against the Arizona Cardinals during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Jacob Kupferman)

Carolina Panthers quarterback Baker Mayfield passes against the Arizona Cardinals during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Jacob Kupferman)

Carolina Panthers quarterback Baker Mayfield passes over Arizona Cardinals linebacker Devon Kennard during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)

Carolina Panthers offensive tackle Ikem Ekwonu plays against the Arizona Cardinals during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)

Carolina Panthers running back Christian McCaffrey is tackled by Arizona Cardinals linebacker Devon Kennard during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)

Carolina Panthers running back Christian McCaffrey runs against the Arizona Cardinals during the first half of an NFL football game on Sunday, Oct. 2, 2022, in Charlotte, N.C. (AP Photo/Rusty Jones)




LB - 49 - Frankie Luvu
CB - 26 - Donte Jackson
LB - 7 - Shaq Thompson


QB - 6 - Baker Mayfield


CB - 8 - Jaycee Horn




LB - 55 - Cory Littleton
S - 25 - Xavier Woods

S - 25 - Xavier Woods

DE - 53 - Brian Burns
CB - 24 - C.J. Henderson

S - 25 - Xavier Woods




DE - 97 - Yetur Gross-Matos
DE - 98 - Marquis Haynes

LB - 49 - Frankie Luvu


DE - 53 - Brian Burns


DT - 99 - Matt Ioannidis


S - 25 - Xavier Woods

DT - 78 - Marquan McCall


LB - 49 - Frankie Luvu
DT - 99 - Matt Ioannidis


CB - 8 - Jaycee Horn

LB - 49 - Frankie Luvu

QB - 6 - Baker Mayfield
RB - 22 - Christian McCaffrey

S - 42 - Sam Franklin Jr.
LB - 55 - Cory Littleton






DT - 99 - Matt Ioannidis

CB - 24 - C.J. Henderson

LB - 7 - Shaq Thompson
DE - 53 - Brian Burns

K - 4 - Eddy Pineiro


LB - 49 - Frankie Luvu

WR - 2 - D.J. Moore

LB - 49 - Frankie Luvu


WR - 15 - Laviska Shenault Jr.


WR - 15 - Laviska Shenault Jr.

WR - 15 - Laviska Shenault Jr.

QB - 6 - Baker Mayfield
RB - 22 - Christian McCaffrey

WR - 2 - D.J. Moore

S - 21 - Jeremy Chinn


LB - 55 - Cory Littleton

WR - 15 - Laviska Shenault Jr.

RB - 22 - Christian McCaffrey

CB - 8 - Jaycee Horn
CB - 24 - C.J. Henderson


QB - 6 - Baker Mayfield

DE - 53 - Brian Burns

CB - 24 - C.J. Henderson
S - 25 - Xavier Woods

CB - 26 - Donte Jackson

LB - 7 - Shaq Thompson

DB - 38 - Myles Hartsfield

LB - 49 - Frankie Luvu
DE - 53 - Brian Burns


DE - 53 - Brian Burns

P - 10 - Johnny Hekker
S - 42 - Sam Franklin
TE - 82 - Tommy Tremble

S - 42 - Sam Franklin
TE - 80 - Ian Thomas

S - 42 - Sam Franklin
P - 10 - Johnny Hekker

WR - 3 - Robbie Anderson


LB - 55 - Cory Littleton

LS - 44 - J.J. Jansen
TE - 45 - Giovanni Ricci

DE - 53 - Brian Burns

LB - 49 - Frankie Luvu


RB - 30 - Chuba Hubbard

DE - 53 - Brian Burns

RB - 30 - Chuba Hubbard