They've only played six times in the regular season.
There haven't been a ton of player or coaching staff overlap between them.
The fan bases seem to…well…get along mostly.
But there's just something a little bit different about the Jacksonville Jaguars.
The Panthers' partner in expansion in 1995; the two mascots from the same genus of the animal family tree; just 380 miles apart.
Some seminal moments in Carolina's 25-year history have happened against Jacksonville or alongside them.
In 1995, the Panthers donned the blue, black and silver for the first time ever in the Hall of Fame preseason game against the Jaguars. It was that day that Bob Christian scored the first-ever touchdown from Frank Reich on a short out route. Carolina won that game 20-14 and went on to have the most successful expansion season in league history.
The next year, the Panthers jumped out to a 3-0 start punctuated by a 23-7 win against San Francisco, the reigning Super Bowl champions. But then they traveled to Jacksonville and were mightily humbled in the stifling Florida heat, 24-14. It was a tough loss and one that Panther fans bristled over at the time.
But it helped refocus a Carolina team that ended up 12-4 and advanced to the NFC Championship game after a monumental home playoff win over Dallas.
Of course, Carolina's run was contextualized by Jacksonville's own unlikely success in 1996. The Jaguars made it to the AFC Championship game the same year and many hoped the two young franchises would meet in the Super Bowl.
Seven years later, in 2003, the Panthers opened the season at home against Jacksonville with Rodney Peete at quarterback. Expectations were growing after new head coach John Fox had brought the Panthers from a 1-15 team in 2001 to a respectable 7-9 in 2002.
But things started poorly against the Jaguars, as Carolina trailed 17-0 at halftime.
The rest is history.
Jake Delhomme replaced Peete at quarterback to open the second half, and was literally so pumped up that teammates had to get him to slow down and repeat the play call because they couldn't understand his Louisiana accent in the huddle.
After two second-half touchdown passes, Delhomme drove the Panthers inside the red zone with less than 20 seconds remaining and Carolina still trailing 17-14. On fourth down, he pumped and lofted a ball to Ricky Proehl in the far corner of the end zone for the game-winning score to beat Jacksonville. It marked the first of a franchise-record seven game-winning drives in the fourth quarter or overtime as the Panthers improbably marched to an appearance in Super Bowl XXXVIII.
Starting to see the trend here?
In 2011, the Jaguars came to Charlotte on a cloudy afternoon with the Panthers still looking for the first win of the season and first wins for rookie quarterback Cam Newton and first-year head coach Ron Rivera.
What ensued was a meteorological anomaly. The skies opened up in the second quarter and buckets and buckets of rain dumped on the field. Cameras could barely follow the ball, not to mention players trying to hang onto it. Ball carriers slid nearly 10 yards after being tackled on the 100-yard long slip and slide that was the field.
Carolina mounted a fourth-quarter comeback with a touchdown catch and two-point conversion from Cam Newton to Greg Olsen and the Panthers recorded the first win of a new era.
The 2015 season had so many moments. So many great wins as Carolina set franchise and NFL records, winning the NFC Championship.
But it all started in Jacksonville in Week 1. On a day when the Panthers were outgained in net yards and clinging to a 10-9 lead in the third quarter with starting wideout Kelvin Benjamin already lost for the season, nobody was thinking about an eventual Super Bowl appearance.
And then Josh Norman intercepted a Blake Bortles pass, ran into the end zone and showed off his signature…personality. It was a defining play in a game that set the table for the season to come.
This Sunday, the Panthers look to climb back in the win column at home as some of the stars of those contests are inducted into the Panthers' Hall of Honor.
Maybe we'll be talking about Panthers-Jaguars 2019 contest for years to come.
Carolina is 3-3 against Jacksonville all-time.
Carolina Panthers quarterback Jake Delhomme (17) celebrates as Jacksonville Jaguars' Danny Clark (54) looks on after Delhomme threw a 12-yard touchdown pass with 16 seconds left in the Panthers' 24-23 win in Charlotte, N.C., Sunday Sept. 7, 2003. (AP Photo/Rusty Burroughs)
Carolina Panthers' Ricky Proehl (81) catches a 12-yard touchdown pass as Jacksonville Jaguars' Jason Craft (29) defends with 16 seconds left in the fourth quarter in the Panthers' 24-23 win in Charlotte, N.C., Sunday, Sept. 7, 2003. (AP Photo/Mike McCarn)
Carolina Panthers quarterback Steve Beuerlein (7) talks with coach George Seifert in the fourth quarter of the Panthers' 22-20 loss to the Jacksonville Jaguars at Ericsson Stadium in Charlotte, N.C., Sunday, Sept. 19, 1999. (AP Photo/Nell Redmond)
Carolina Panthers' Cam Newton (1) scrambles as Jacksonville Jaguars' Jeremy Mincey (94) pursues during the fourth quarter of the Panthers' 16-10 win in an NFL football game in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Chuck Burton)
Carolina Panthers' Cam Newton (1) is hit by Jacksonville Jaguars' Jeremy Mincey (94) and John Chick (97) during the second quarter of an NFL football game in the rain in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Bob Leverone)
Carolina Panthers' Jonathan Stewart (28) runs in the heavy rains as Jacksonville Jaguars' Drew Coleman (30) tries to catch during an NFL football game in Charlotte, N.C., Sunday, Sept. 25, 2011. The Carolina Panthers defeated the Jacksonville Jaguars 16-10. (AP Photo/Bob Leverone)
Carolina Panthers' Cam Newton (1) and Greg Olsen (88) celebrate their touchdown against the Jacksonville Jaguars during the fourth quarter of the Panthers' 16-10 win in an NFL football game in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Nell Redmond)
Carolina Panthers' Greg Olsen (88) celebrates his touchdown catch as Jacksonville Jaguars' Dwight Lowery (25) looks on during the fourth quarter of the Panthers' 16-10 win in an NFL football game in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Nell Redmond)
Jacksonville Jaguars' Mike Thomas (80) dives into the end zone for a touchdown against the Carolina Panthers at the end of the second quarter of an NFL football game in the rain in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Nell Redmond)
Jacksonville Jaguars' Maurice Jones-Drew (32) is tackled by Carolina Panthers' Captain Munnerlyn (41) and Jason Williams (54) during the third quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 25, 2011. (AP Photo/Bob Leverone)
Carolina Panthers' Mike Minter (30) blocks a last-second field goal attempt by Jacksonville Jaguars' Seth Marler (6) in the fourth quarter of the Panthers' 24-23 win in Charlotte, N.C., Sunday Sept. 7, 2003. (AP Photo/Rick Havner)
Jacksonville Jaguars center Stefen Wisniewski (61) blocks Carolina Panthers defensive tackle Kawann Short (99) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP photo/ Rick Wilson)
Carolina Panthers defensive end Wes Horton (96) chases scrambling Jacksonville Jaguars quarterback Blake Bortles (5) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars linebacker Telvin Smith (50) tackles Carolina Panthers running back Fozzy Whittaker (43) knocking out his mouthpiece in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
FILE - In this Sept. 13, 2015, file photo, Carolina Panthers cornerback Josh Norman (24) runs back an interception against the Jacksonville Jaguars for a 30-yard touchdown during the second half of an NFL football game in Jacksonville, Fla. The Panthers have struggled this season after pulling the franchise tag from cornerback Josh Norman this offseason, allowing him to join the Washington Redskins as a free agent. (AP Photo/Phelan M. Ebenhack, File)
Jacksonville Jaguars quarterback Mark Brunell (8) is sacked by Carolina Panthers' Kris Jenkins (77) after tripping on center Brad Meester (63) in the first quarter in Charlotte, N.C., Sunday, Sept. 7, 2003. (AP Photo/Rusty Burroughs)
Jacksonville Jaguars defensive tackle Abry Jones (95) gets his hands up to pressure Carolina Panthers quarterback Cam Newton (1) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars rookie free agent running back Corey Grant (33) is tackled by Carolina Panthers cornerback Charles Tillman (31) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Carolina Panthers quarterback Cam Newton (1) is tackled by Jacksonville Jaguars outside linebacker Telvin Smith (50) and defensive tackle Jared Odrick, bottom, during the second half of an NFL football game in Jacksonville, Fla., Sunday, Sept. 13, 2015. Carolina won 20-9. (AP Photo/Phelan M. Ebenhack)
Jacksonville Jaguars quarterback Blake Bortles (5) throws a pass against the Carolina Panthers in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars rookie running back T.J. Yeldon (24) drags a Carolina Panthers defensive player as he rushes for a 12 yard gain with 13:32 to play in the fourth quarter in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars quarterback Blake Bortles (5) is sacked for a one yard loss by Carolina Panthers defensive end Mario Addison (97) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars rookie running back T.J. Yeldon (24) rushes for a 12 yard gain with 13:32 to play in the fourth quarter against the Carolina Panthers in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Carolina Panthers Ted Ginn Jr. (19) returns a punt against the Jacksonville Jaguars in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/Rick Wilson)
Jacksonville Jaguars defensive tackle Abry Jones (95) pressures Carolina Panthers quarterback Cam Newton (1) in an NFL game, Sunday, Sept. 13, 2015, in Jacksonville, Fla. (AP Photo/ Rick Wilson)
Carolina Panthers Chris Gamble, left, breaks up a pass intended for Jacksonville Jaguars receiver Ernest Wilford during the first quarter of a National Football League game, Sunday, Dec. 9, 2007, in Jacksonville, Fla. (AP Photo/Phil Coale)
Carolina Panthers quarterback Vinny Testaverde (16) drops back to pass during the fourth quarter of a National Football League game against the Jacksonville Jaguars, Sunday, Dec. 9, 2007, in Jacksonville, Fla. Jacksonville won, 34-6. (AP Photo/Phil Coale)
Carolina Panthers running back DeShaun Foster, top, is tackled by Jacksonville Jaguars Brian Williams during the first quarter of a National Football League game, Sunday, Dec. 9, 2007, in Jacksonville, Fla. (AP Photo/Phil Coale)
Jacksonville Jaguars quarterback David Garrard, center, winds up in the arms of Carolina Panthers Kris Jenkins, left, as he tries to scramble during the first quarter of an NFL game, Sunday, Dec. 9, 2007, in Jacksonville, Fla. Jacksonville won 34-6. (AP Photo/Phil Coale)
