CHARLOTTE - Over the last couple of weeks in the NFL, it's become more difficult to predict what will happen on Sunday afternoons. Or Saturdays. Or Mondays. Or Tuesdays.
This is because the COVID-19 Omicron variant is wreaking havoc on teams' rosters.
Take the New Orleans Saints (7-8), for example.
One week after shutting out Tom Brady and the New Orleans Saints, the Saints were soundly beaten, 20-3, by Miami on Monday Night Football.
New Orleans managed just 164 yards of offense as Ian Book started the first game of his career at quarterback.
Let's take a look at the Saints in Week 17.
COVID LIST
Prior to Monday's game, the Saints had 22 players on the reserve/COVID-19 list, including quarterbacks Taysom Hill and Trevor Siemian, offensive linemen Ryan Ramczyk and Jordan Mills, linebackers Demario Davis and Kwon Alexander and safety Malcolm Jenkins.
As we've seen from around the NFL the last two weeks, several players could all be back by Sunday, some could still be on the list, and others might be added by that time.
The Panthers coaching staff will be throwing darts at a moving board in terms of game planning against such a roster in flux (admittedly, the same goes for New Orleans after the Panthers put six players on the COVID-19 list on Monday).
QUESTIONS AT QUARTERBACK
Even before Book was pressed into service at quarterback on Monday, the Saints weren't necessarily settled at quarterback. Hill started the previous three games, going 2-1 but completing just 52.8 percent of his passes for 197.6 yards per game and a passer rating of 62.6.
In the four weeks before that, Siemian went 0-4 with a 57.6 completion percentage, 231.0 yards per game and an 86.7 passer rating.
At the least, the Panthers won't be facing a passing attack of the likes of Tom Brady, Josh Allen or Matt Ryan on Sunday.
STRONG AGAINST THE RUN
Since Week 9, the Saints boast the NFL's best defensive rush EPA (+47.6), allowing just 3.87 yards per rush while forcing three fumbles and making 40 tackles for loss.
Cameron Jordan has nine tackles for loss to go with a team-high 8.0 sacks and 18 QB hits. Jordan recently cracked 100 career sacks and now ranks 31st in NFL history with 102.5 sacks.
STILL IN THE HUNT
Although they will need some help down the stretch, the Saints are still playing for the final wild card spots in the NFC.
The 49ers, Eagles, Vikings, Falcons and Saints are all within one game of each other and fighting for two wild card spots. Results in divisional matchups in the final two weeks will have a significant bearing on tiebreakers, so the Saints will be very motivated to find a win over Carolina on Sunday.
The Panthers trail the all-time series against the Saints, 27-29. Carolina has played New Orleans more than any other team in its history.
Carolina Panther Luke Kuechly (59) keeps his eyes on New Orleans Saint quarterback Drew Brees at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers' Rod Smart (32) runs past cheering teammates for a 100-yard kick return for a touchdown during the second quarter against the New Orleans Saints in Charlotte, N.C., Sunday Oct. 5, 2003. (AP Photo/Rick Havner)
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panther Christian McCaffrey (22) makes a reception in the red zone against the New Orleans Saints at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers running back DeAngelo Williams in action during an NFL football game against the New Orleans Saints in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Chuck Burton)
Carolina Panther Curtis Samuel (10) evades New Orleans Saints Marcus Williams at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
New Orleans Saints defenders Roman Harper (41) and Jason David (42) try to defend Carolina Panthers wide receiver Steve Smith (89) in the second half of their NFL football game in the Superdome in New Orleans, Sunday, Dec. 28, 2008. Smith caught the long pass to keep the Panthers' game-winning drive alive as they defeated the Saints 33-31. (AP Photo/Chris Martinez)
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
New Orleans Saints' Drew Brees (9) looks to pass as Carolina Panthers' Julius Peppers (90) defends during the second quarter of an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Chuck Burton)
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers against the New Orleans Saints during the wild card round of the NFL playoffs at the Mercedes-Benz Superdome on Sunday, January 7, 2018 in New Orleans, LA. (Photo by Melissa Melvin-Rodriguez)
Carolina Panthers quarterback Jake Delhomme (17) scrambles as New Orleans Saints' Charles Grant (94) pursues during the second half of the Panthers' 30-7 win in an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Rick Havner)
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
New Orleans Saints quarterback Drew Brees (9) is sacked by Carolina Panthers outside linebacker Thomas Davis in the second half of an NFL football game in New Orleans, Sunday, Dec. 6, 2015. (AP Photo/Jonathan Bachman)
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
New Orleans Saints kicker Olindo Mare right, tries to grab the ball as Steve Weatherford (7) scrambles with Carolina Panthers Richard Marshall after the kick was blocked in the second half of their football game in the Superdome in New Orleans Sunday, Oct. 7, 2007. The Panthers won 16-13.(AP Photo/Alex Brandon)
Carolina Panthers receiver Steve Smith (89) gets by New Orleans Saints cornerback Fred Thomas on his way to a 15-yard, third-quarter touchdown during an NFL football game in Baton Rouge, La., on Sunday, Dec. 18, 2005. The Panthers won 27-10. (AP Photo/Paul Rutherford)
New Orleans Saints quarterback Drew Brees, bottom, lies on the field after being sacked by Carolina Panthers defender Richard Marshall (31) in the second half of their NFL football game in the Superdome in New Orleans, Sunday, Dec. 28, 2008.(AP Photo/Alex Brandon)
Carolina Panthers linebacker Mark Fields (58) celebrates sacking New Orleans Saints quarterback Aaron Brooks (2), center, on ground (partially obscured), at the Louisiana Superdome in New Orleans, Sunday, Dec. 29, 2002. The Panthers defeated the Saints, 10-6. On ground at right is Saints' Spencer Folau.(AP Photo/Doug Keese)
Carolina Panthers' Ken Lucas, left, intercepts a pass intended for New Orleans Saints' Marques Colston, right, during the third quarter of the Panthers' 30-7 win in an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Rick Havner)
Carolina Panthers quarterback Matt Moore (3) scrambles during an NFL football game against the New Orleans Saints in Charlotte, N.C., Sunday, Nov. 25, 2007. (AP Photo/Mike McCarn)
Carolina Panthers kicker John Kasay, center, is surrounded by his teammates after his field goal as time expired in an NFL football game in the Superdome in New Orleans on Sunday, Oct. 7, 2007. The Panthers won 16-13. (AP Photo/Alex Brandon)
The celebration begins as Carolina Panthers' Todd Sauerbrun (10) John Kasay (4) and Kris Mangum (86) enjoy their 23-20 victory over the New Orleans Saints, Sunday, Oct. 26, 2003, in the Louisiana Superdome in New Orleans. Kasay kicked the game-winning field goal in overtime. Leave the field for the Saints is Jay Bellamy (20). Holding for Kasay was punter Todd Souerbrun (10). (AP Photo/Andrew Cohoon)
New Orleans Saints defenders Johnathan Sullivan, left, and Brian Young (66) pursue Carolina Panthers quarterback Jake Delhomme (17) during the first half of an NFL football game at LSU's Tiger Stadium on Sunday, Dec. 18, 2005, in Baton Rouge, La. The Panthers won 27-10. (AP Photo/Bill Feig)
