CHARLOTTE – Running back Jonathan Stewart, who entered Sunday's game against the 49ers questionable with an ankle injury, left the game with a hamstring injury in the first half. He was ruled out for the remainder of the game at the start of the second half.
Stewart started the game and rushed five times for 9 yards. He also caught two passes for 7 yards.
He was taken to the locker room and did not return to the sideline. Fozzy Whittaker and Mike Tolbert carried the load in his absence.
When asked about the level of concern regarding Stewart's injury after the game, head coach Ron Rivera said, "A little bit. We will see how it is... I thought (Fozzy) and Mike mixed it up well.
"If (Stewart's injury) is prolonged, then we certainly will get an opportunity to see Cameron Artis-Payne out there, which I'm pretty excited about because he is a heck of a young player."
View game action photos from Carolina's 46-27 win over San Francisco.
Carolina Panthers' Cam Newton (1) looks to pass against the San Francisco 49ers in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Cam Newton (1) looks to pass under pressure from San Francisco 49ers' Ahmad Brooks (55) in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Chuck Burton)
Carolina Panthers' Shaq Thompson (54) runs toward the end zone for a touchdown after recovering a San Francisco 49ers fumble in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
San Francisco 49ers' Shaun Draughn (24) is tackled by Carolina Panthers' Tre Boston (33) in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Cam Newton (1) looks to pass over San Francisco 49ers' Ray-Ray Armstrong (54) in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
San Francisco 49ers' Chris Davis, center, and Ray-Ray Armstrong, right, try to recover a fumble by Carolina Panthers' Fozzy Whittaker, left, in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The 49ers recovered the ball. (AP Photo/Mike McCarn)
San Francisco 49ers' Blaine Gabbert (2) looks to pass against the Carolina Panthers in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
San Francisco 49ers' Rod Streater (81) celebrates after making a first down against the Carolina Panthers in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Greg Olsen (88) runs past San Francisco 49ers' Antoine Bethea (41) for a touchdown after a catch in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Greg Olsen (88) celebrates his touchdown catch as San Francisco 49ers' Tramaine Brock (26) watches in the first quarter of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
San Francisco 49ers' Blaine Gabbert (2) tries to avoid the rush of Carolina Panthers' Charles Johnson (95) in the first half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Cam Newton (1) runs for a gain past San Francisco 49ers' NaVorro Bowman (53) in the first half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Cam Newton (1) celebrates after making a first down against the San Francisco 49ers in the first half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Kelvin Benjamin, back, catches a pass as San Francisco 49ers' Jimmie Ward, front, defends in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Kelvin Benjamin (13) catches a touchdown pass as San Francisco 49ers' Jimmie Ward (25) and Antoine Bethea (41) defend in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
San Francisco 49ers' Blaine Gabbert (2) looks to pass against the Carolina Panthers in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Kelvin Benjamin (13) runs into the end zone past San Francisco 49ers' Jaquiski Tartt (29) for a touchdown in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Cam Newton (1) fumbles the football as San Francisco 49ers' Eli Harold (58) watches in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The 49ers recovered the ball. (AP Photo/Mike McCarn)
Carolina Panthers' Ted Ginn (19) fumbles the kickoff by the San Francisco 49ers in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The 49ers recovered the ball. (AP Photo/Bob Leverone)
San Francisco 49ers' Shaun Draughn, left, recovers a Carolina Panthers fumble as Carolina Panthers' Jeremy Cash (57) defends in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
San Francisco 49ers' Blaine Gabbert (2) runs into the end zone for a touchdown against the Carolina Panthers in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
San Francisco 49ers' Vance McDonald (89) runs past Carolina Panthers' Luke Kuechly (59) for a touchdown in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Bob Leverone)
Carolina Panthers' Kelvin Benjamin (13) catches a pass as San Francisco 49ers' Chris Davis (43) defends in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The Panthers won 46-27. (AP Photo/Bob Leverone)
Carolina Panthers' Kelvin Benjamin (13) reacts to making a catch against San Francisco 49ers' Eric Reid (35) in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Fozzy Whittaker (43) runs past San Francisco 49ers' Eric Reid (35) in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
San Francisco 49ers' Vance McDonald (89) misses a catch as Carolina Panthers' Kurt Coleman (20) defends in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The Panthers won 46-27. (AP Photo/Bob Leverone)
Carolina Panthers' Luke Kuechly (59) celebrates after intercepting a pass intended for San Francisco 49ers' Jeremy Kerley (17) in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
Carolina Panthers' Devin Funchess (17) catches a touchdown pass as San Francisco 49ers' Antoine Bethea (41) defends in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. (AP Photo/Mike McCarn)
San Francisco 49ers' Blaine Gabbert (2) looks to pass under pressure from Carolina Panthers' Mario Addison (97) in the second half of an NFL football game in Charlotte, N.C., Sunday, Sept. 18, 2016. The Panthers won 46-27. (AP Photo/Mike McCarn)
Carolina Panthers' Cam Newton (1) celebrates after an NFL football game San Francisco 49ers in Charlotte, N.C., Sunday, Sept. 18, 2016. The Panthers won 46-27. (AP Photo/Bob Leverone)
