The Panthers are 5-8 all-time against the Eagles. Carolina is 2-4 at home and 3-4 on the road with a 1-0 record in the playoffs.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 10/27/96 | at Philadelphia | L | 9-20 |
| 11/7/99 | PHILADELPHIA | W | 33-7 |
| 11/30/03 | PHILADELPHIA | L | 16-25 |
| 1/18/04 | at Philadelphia | W | 14-3 (NFC Championship) |
| 10/17/04 | at Philadelphia | L | 8-30 |
| 12/4/06 | at Philadelphia | L | 24-27 (MNF) |
| 9/13/09 | PHILADELPHIA | L | 10-38 |
| 11/26/12 | at Philadelphia | W | 30-22 (MNF) |
| 11/10/14 | at Philadelphia | L | 21-45 (MNF) |
| 10/25/15 | PHILADELPHIA | W | 27-16 (SNF) |
| 10/12/17 | PHILADELPHIA | L | 23-28 (TNF) |
| 10/21/18 | at Philadelphia | W | 21-17 |
| 10/10/21 | PHILADELPHIA | L | 18-21 |