The Panthers are 13-10 all-time against the Rams. Carolina is 6-5 at home and 7-5 on the road at the Rams, including a playoff win in 2003.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 9/17/95 | ST. LOUIS | L | 10-13 |
| 11/12/95 | at St. Louis | L | 17-28 |
| 10/13/96 | ST. LOUIS | W | 45-13 |
| 11/17/96 | at St. Louis | W | 20-10 |
| 11/23/97 | at St. Louis | W | 16-10 |
| 12/20/97 | ST. LOUIS | L | 18-30 |
| 11/22/98 | at St. Louis | W | 24-20 |
| 12/20/98 | ST. LOUIS | W | 20-13 |
| 11/14/99 | at St. Louis | L | 10-35 |
| 12/5/99 | ST. LOUIS | L | 21-34 |
| 11/5/00 | at St. Louis | W | 27-24 (SNF) |
| 12/3/00 | ST. LOUIS | W | 16-3 |
| 11/11/01 | at St. Louis | L | 14-48 |
| 12/23/01 | ST. LOUIS | L | 32-38 |
| 1/10/04 | at St. Louis | W | 29-23 (2OT) (NFC Divisional) |
| 12/12/04 | ST. LOUIS | W | 20-7 |
| 11/19/06 | ST. LOUIS | W | 15-0 |
| 9/9/07 | at St. Louis | W | 27-13 |
| 10/31/10 | at St. Louis | L | 10-20 |
| 10/20/13 | ST. LOUIS | W | 30-15 |
| 11/6/16 | at Los Angeles | W | 13-10 |
| 9/8/19 | LOS ANGELES | L | 27-30 |
| 10/16/22 | at Los Angeles | L | 10-24 |