The Panthers are 6-1 all-time against the Chargers. Carolina is 2-1 at home and 4-0 on the road.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 9/14/97 | at San Diego | W | 26-7 |
| 12/17/00 | SAN DIEGO | W | 30-22 |
| 10/24/04 | SAN DIEGO | L | 6-17 |
| 9/7/08 | at San Diego | W | 26-24 |
| 12/16/12 | at San Diego | W | 31-7 |
| 12/11/16 | SAN DIEGO | W | 28-16 |
| 9/27/20 | at Los Angeles | W | 21-16 |