The Panthers are 5-2 all-time against the Colts. Carolina is 2-1 at home and 3-1 on the road at Indianapolis.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 12/3/95 | INDIANAPOLIS | W | 13-10 |
| 12/27/98 | at Indianapolis | W | 27-19 |
| 10/12/03 | at Indianapolis | W | 23-20 (OT) |
| 10/28/07 | INDIANAPOLIS | L | 7-31 |
| 11/27/11 | at Indianapolis | W | 27-19 |
| 11/2/15 | INDIANAPOLIS | W | 29-26 (OT) (MNF) |
| 12/22/19 | at Indianapolis | L | 6-38 |