The Panthers are 4-2 all-time against the Texans. Carolina is 1-1 at home and 3-1 on the road at Houston.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 11/2/03 | at Houston | L | 10-14 |
| 9/16/07 | HOUSTON | L | 21-34 |
| 12/18/11 | at Houston | W | 28-13 |
| 9/20/15 | HOUSTON | W | 24-17 |
| 9/29/19 | at Houston | W | 16-10 |
| 9/23/21 | at Houston | W | 24-9 |