The Panthers are 8-4 all-time against the Lions. Carolina is 6-1 at home and 2-2 on the road.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 10/24/99 | DETROIT | L | 9-24 |
| 9/15/02 | DETROIT | W | 31-7 |
| 12/21/03 | DETROIT | W | 20-14 |
| 10/16/05 | at Detroit | W | 21-20 |
| 11/16/08 | DETROIT | W | 31-22 |
| 11/20/11 | at Detroit | L | 35-49 |
| 9/14/14 | DETROIT | W | 24-7 |
| 10/8/17 | at Detroit | W | 27-24 |
| 11/18/18 | at Detroit | L | 19-20 |
| 11/22/20 | DETROIT | W | 20-0 |
| 12/24/22 | DETROIT | W | 37-23 |