The Panthers are 2-6 all-time against the Broncos. Carolina is 2-2 at home and 0-3 on the road. Carolina lost Super Bowl 50 to Denver in San Francisco.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 11/9/97 | at Denver | L | 0-34 |
| 10/10/04 | at Denver | L | 17-20 |
| 12/14/08 | DENVER | W | 30-10 |
| 11/11/12 | DENVER | L | 14-36 |
| 2/7/16 | vs. Denver | L | 10-24 (Super Bowl 50) |
| 9/8/16 | at Denver | L | 20-21 |
| 12/13/20 | DENVER | L | 27-32 |
| 11/27/22 | DENVER | W | 23-10 |