The Panthers are 3-3-1 all-time against the Bengals. Carolina is 3-1 at home and 0-2-1 on the road at Cincinnati. The Bengals are the only team that the Panthers have ever tied in franchise history.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 9/26/99 | CINCINNATI | W | 27-3 |
| 12/8/02 | CINCINNATI | W | 52-31 |
| 10/22/06 | at Cincinnati | L | 14-17 |
| 9/26/10 | CINCINNATI | L | 7-20 |
| 10/12/14 | at Cincinnati | T | 37-37 |
| 9/23/18 | CINCINNATI | W | 31-21 |
| 11/6/22 | at Cincinnati | L | 21-42 |