The Panthers are 2-6 all-time against the Bills. Carolina is 1-2 at home and 1-4 on the road at Buffalo.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 9/10/95 | at Buffalo | L | 9-31 |
| 10/25/98 | BUFFALO | L | 14-30 (SNF) |
| 12/9/01 | at Buffalo | L | 24-25 |
| 11/27/05 | at Buffalo | W | 13-9 |
| 10/25/09 | BUFFALO | L | 9-20 |
| 9/15/13 | at Buffalo | L | 23-24 |
| 9/17/17 | BUFFALO | W | 9-3 |
| 12/19/21 | at Buffalo | L | 14-31 |